The Incredible Shrinking Man (Part 3)

by | Jul 14, 2026 | Fitness, Health Care, LifeSkills, Science | 77 comments

The first post in this series was mostly informational to explain what the new GLP-1 medications are and how they work according to the publicly-available media sources.   The second post was mostly an accounting of my 50-year history of trying and failing to control my weight.  This post is intended to explore what Zepbound is doing to make me suddenly successful at something I couldn’t do for 50 years.

Disclaimer:

I am currently at 74 lbs total weight loss or 25.8% loss from my starting weight.  This is at the 58-week point (14 weeks shorter than the 72-week trial period in the published trials for Zepbound).   My results are much better than those achieved by the majority of people in the trial, and this implies my personal results might be somewhat out of the ordinary for most people.

Personal Results:

I lost the first 20 lbs in eleven weeks averaging just under 2 lbs a week.  The second 20 lbs took 16 weeks, and the third 20 lbs also took 16.  So, in total, I was down 60 lbs in just 43 weeks.    The last 18 weeks have resulted in an additional 14 lb loss.   It is likely at this point that weight loss will continue to average 1 lb or less per week going forward.  It really isn’t possible to sustain the 1 ½ to 2 lbs per week loss without more drastic cutbacks in food intake.  And yes, it is a bit disappointing to see things slow down.  But the initial rapid weight loss is definitely great for morale after 50 years of general failure.

So, now we can get into what Zepbound is doing to me (or for me).

It’s Like Science and Shit:

Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation

What it does:

  • Centrally, GLP-1 RAs modulate brain regions controlling appetite, influencing neurotransmitter and peptide release to regulate hunger and energy expenditure.
  • Peripherally, GLP-1 RAs improve glycemic control by enhancing insulin secretion, reducing glucagon release, delaying gastric emptying, and regulating gut hormones.
  • They also reduce triglycerides and low-density lipoprotein cholesterol, mitigate adipose tissue inflammation, and minimize ectopic fat deposition, promoting overall metabolic health.

It’s so easy to understand.  You eat less, because you want less.  And your body is more efficient at using calories and is less likely to store them.  So, you lose weight.  Hip hip hooray!

Except, that doesn’t come close to explaining my internal experiences of being on Zepbound.

What It Feels Like in Your Head:

When I first talked to the doctor about starting Zepbound, he explained it the way the science explains it (as above).  He mentioned that other patients had talked about getting lost in work and forgetting to eat lunch because they weren’t hungry.  But that’s not how I experienced the changes in appetite that occurred.

Remember from Part 2 that I was already following a fairly rigorous schedule of eating 5 times a day.  That didn’t change once I started this journey.  I didn’t lose my appetite; I still felt hungry when the schedule said it was time to eat.   The changes were more subtle than that – it changed how much I wanted to eat not when I wanted to eat.

At about the 5-week mark, I reached into the lunch box and grabbed a lunch that I had probably made a few months earlier (I frequently make 8 or 10 lunches at the same time, and they all go into the chest freezer).   While carrying it to the microwave, I had this weird reaction – man this feels so heavy – why does it feel so heavy?   I nuked it the same as usual and took it back to my desk.  Then I popped off the lid and thought “I can’t eat that much food – what the fuck was I thinking about when I made this”.   A moment later a second thought came through “Huh, this must be how the brains of normal people work”.  So, I ate as much as I wanted and threw the rest away.  I went home and started making smaller lunches while working my way through the backlog of lunches in the chest freezer. 

This scenario, and many like it, would be repeated many times over the next year.  One day, my wife and I went to a restaurant.  We ordered, and then the staff brought out a plate and dropped it in front of me.   My immediate reaction was “you got to be kidding; I can’t eat that”.   As result, my wife and I have pretty much stopped going out to eat.   Around 4 months ago, I suddenly found that I could not stand anything sweet.   I now cringe thinking about things I used to like but can’t tolerate anymore.

The net result over the last year has been a dramatic change in my behavior.   But every change was a response to a gut-level reaction of “I just can’t eat that anymore” or “I don’t want that anymore” or “I don’t like that anymore”.   There has been no conscious planning involved in changing my behavior.

At this point, I am not following any kind of diet program.  I just simply eat less of everything.   I don’t avoid any kinds of food in particular (except for fucking sweets), nor do I focus on trying to eat anything in particular (fuck keto – a quick wink to all my friends here).

Fair Warning:  Engineer dives into pop psychology

I spent a lot of time trying to figure out how to explain the impacts that Zepbound has had on my internal thinking.   Nothing in the scientific explanations that I have read get around to explaining the changes in what I feel and what I want.  Anyone that has ever taken an appetite suppressant (yes desperation leads to bad choices) will recognize the physical experience of “I am empty, but I don’t care”.   This is completely different than thinking “hey it’s time for lunch”, and then making or buying a small lunch instead of the huge lunch you used to eat and being completely satisfied with less.

And then I got the idea of using Freud to explain it:

  • Id: The unconscious, infantile part of the psyche present from birth, driven by the pleasure principle to seek immediate gratification of basic instincts like hunger and aggression.
  • Ego: The rational mediator operating on the reality principle, which balances the id’s impulses with external constraints and social norms.
  • Superego: The moral conscience incorporating societal and parental standards, striving for perfection and inducing guilt for wrongdoings.

So, let us dive in to the id and the ego (no one gives a shit about the superego – there are no angels amongst us).

The first part of my theory is the id controls your weight.  Period.  End of story.

Now the ego disagrees mightily.   The ego decides what it wants us to weigh.  The ego makes plans.  The ego mounts a campaign; wins some battles; and advances steadily towards the final goal.  But at some point, the id digs in; progress stalls; and then months or even years later; the id has regained all the lost territory and you wind up weighing whatever you weighed when the ego thought it could take control.

The id always wins. Period.  End of story.

This may sound like me just trying to justify my own personal moral failings over the last 50 years.  But I know three people that went through Roux-en-Y gastric bypass (RYGB) surgery.  This surgery provides rapid and drastic weight loss; people can lose 30% to 35% of their starting weight.  And yet after three or four years, all three of these people had regained most of their weight.  Because, the surgery does not fix whatever problem had led them to be overweight in the first place.

The id always wins. Period.  End of story.

This leads to the second part of my theory which is that Zepbound slowly reprograms your id.  You lose weight because the id wants you to.  It’s just that simple.   The ego follows along, proud of all that we achieve.   Sure, the ego is what gets us to the doctor; pays for the scripts, and injects the magic juice every week.   But the weight comes off because the id decides to live in a smaller body.

Conclusions:

It not possible to overstate how profound the changes have been in the way my mind works.   The compulsion to eat – that I struggled with for more than 5 decades – is gone.   Not diminished.  Just flat out gone.  There is no overeating, no stress eating, no going bonkers when I get taken out of my normal routine.   My wife and I took a 10-day vacation last spring for our fiftieth anniversary.   We spent a day and a half on the road both ways eating fast food or junk food on the road.   We eat at restaurants every night we were on vacation.  This is the kind of break in my routine that would normally result in gaining 6 lbs or 8 lbs or even 10 lbs over the course of the trip.   But on this trip, I lost 3 lbs, because my eating was never out of control.

And another completely unexpected benefit from being on Zepbound was that my insomnia has disappeared.  I have seen nothing in the media that even hints that that is a known effect of taking GLP-1 medicines.

In summary, this has been the easiest year of my life.  All the changes in my behavior over the last year have essentially been effortless.  So, as far as I am concerned, Zepbound is fucking magic, and I don’t ever want to stop taking it.

Addendum:

When working on Part 1, I came across this bit of information: Appetite and Satiety: By acting on the brain’s hypothalamus, these drugs reduce hunger, increase feelings of fullness, and decrease food cravings.

I had read many times that GLP-1 drugs act on the brain to increase satisfaction and reduce the appetite.  But this is the first time that I had read that the drugs act on the hypothalamus.

That seems important.  So, what is the hypothalamus?

The hypothalamus is a small, almond-sized structure located deep in the brain, below the thalamus and above the pituitary gland.  It serves as the primary link between the nervous system and the endocrine system, acting as the body’s central control center for maintaining homeostasis.

This structure regulates critical physiological processes through direct neural signals and hormone production. Key functions include:

  • Thermoregulation: Controlling body temperature via sweating or shivering.
  • Hormone Regulation: Producing releasing hormones (like TRH, CRH, GnRH) that stimulate the pituitary gland, and synthesizing oxytocin and vasopressin.
  • Autonomic Functions: Managing heart rate, blood pressure, and fluid balance.
  • Behavioral Needs: Controlling hunger, thirst, sleep-wake cycles (circadian rhythms), and sexual drive.
  • Emotional Response: Influencing emotional expression and stress responses via the limbic system.

OK, that is a bunch of important stuff.

So, how does GLP-1 effect to the hypothalamus?

GLP-1 targets the hypothalamus to profoundly regulate appetite, metabolism, and energy expenditure.   GLP-1 interacts with several key hypothalamic nuclei to produce these effects:

  • Arcuate Nucleus (ARC): The metabolic switchboard of the brain. GLP-1 activates neurons that release appetite-suppressing peptides (POMC) while inhibiting neurons that release hunger-stimulating peptides (NPY).
  • Paraventricular Nucleus (PVN): Plays a major role in regulating food intake and the body’s stress response. GLP-1 signaling in this area also activates the sympathetic nervous system, which can influence heart rate and metabolic rate.
  • Dorsomedial Hypothalamus (DMH): Known for regulating energy expenditure. GLP-1 activation in the DMH increases brown adipose tissue (BAT) thermogenesis, helping the body burn more calories as heat.
  • Lateral Hypothalamus (LH): Helps control food reinforcement and palatability. GLP-1 signaling here suppresses the rewarding aspects of food, which helps reduce “food noise” and cravings.

In summary, Zepbound is actually fucking around in your brain at the level of your base instincts (i.e., your Id).   That’s OK.  I like it.

About The Author

kinnath

kinnath

I am not a bum. I'm a jerk. I once had wealth, power, and the love of a beautiful woman. Now I only have two things: the glibs, and... uh... my booze.

77 Comments

  1. rhywun

    Zepbound is actually fucking around in your brain at the level of your base instincts

    Huh. That sounds terrifying.

    • kinnath

      In my case, it was a blessing.

  2. UnCivilServant

    You are wrong.

    Copy-paste the above in response to any claim not tied to your specific datum.

    I’ve summed up the remainder of the discussion.

    • kinnath

      Thank you. I appreciate your efficiency.

      • UnCivilServant

        I was hoping to elicit a chuckle.

        Or scorn. Scorn works too.

      • kinnath

        You earned both. But I was also trying to be efficient.

  3. Michael Malaise

    Are you adding strength training of some sort because I would recommend that.

    My wife had to go on a GLP-1 due to sudden weight gain from another medication. It was like 35 pounds in 9 months. Exasperated went to NP who put her on Wegovy. She dropped 45 pounds fairly quickly. She’s always watched what she’s eaten and got moderate exercise. For several years she ran and did 5 half-marathons in one year. The other meds basically killed her metabolism.

    Now she’s a Hotworx (sauna-based workouts) regular and is adding strength training to help her as she ages. It’s a bit of a struggle for her and I feel bad even though she looks f-ing amazing for her age (50)

    • kinnath

      Are you adding strength training

      yes

      • J. Frank Parnell

        Are you seeing decent strength gains while on it?

        I finally broke the habit of just going to the gym and doing whatever machine was open and started on an actual scheduled, planned, and tracked strength-training regimen a few months ago. I’m getting stronger but it’s not doing anything for the 30-40 pounds of gut fat I need to lose.

      • kinnath

        At this point, my focus is on maintaining muscle mass and strength. Not really trying to build anything yet.

        I think I made the point in the first article that you lose muscle to atrophy strictly from living in a smaller body. You’re lifting 75 pounds less out of a chair a couple of dozen times a day. You are carrying less going up the stairs. You can carrying less just walking around.

        As a senior citizen, your muscles are quick to decide they don’t need to be that big if you’re not that big.

        I am doing chair squats (cause I don’t trust my knees to do standard squats). I am using a pair of 30 lb dumbbells. So, I am lifting my body weight plus 60 lbs for each squat. So, less than what I weighed 14 months ago.

        On the other hand, 14 months ago, I couldn’t do 3 sets of 10 squats in short order as excerise.

        So yeah, getting stronger but more in terms of stamina than raw strength.

      • Threedoor

        The glps seem to mimic the hormonal signaling of fasting. Throw in some increased exercise and I can see it having a similar impact.

      • trshmnstr

        it’s not doing anything for the 30-40 pounds of gut fat I need to lose

        I’ve found that strength training makes my appetite even stronger. I have more energy and discipline to ignore the pangs, but I feel hungry every 2 hours.

        Protein shakes do seem to help, but they’re calorie bombs that you may not realize if you’re not watching your intake carefully.

      • Fourscore

        After my accident 5 years ago I was encouraged to consume more protein and calcium as a healing agent. Somewhere about 2 years ago I started drinking the commercial protein shakes. Without paying attention I added 20 lbs around the belly. Then I noticed that constipation became a regular occurrence.

        The constipation kept on keeping on and it was a serious problem. I finally checked the ingredients in the shakes, there was a very long list of chemicals that I couldn’t pronounce and not a single plant/animal source. I stopped the extra 30 gram stuff, within a day or two I began to get better. I re-evaluated my eating habits, cut out the sweets, even the honey I enjoyed on my oatmeal. I have lost a few lbs but best of all is I feel better.

        My wife started sneaking my protein shakes a few months ago. A few days ago I noticed that she was spending a lot of time in the bathroom. I encouraged her to stop the shakes, starting yesterday. Today she has a smile and I think she also is permanently off the phony protein.

    • DrOtto

      I pronounce that ‘Ho-twerx’ to the bemusement of my wife and kids.

  4. Sean

    fuck keto

    You do you. I couldn’t be happier.

    😛

    • PutridMeat

      GLP-1 is a hormone produced in the guts; GLP-1 agonists mimic the action of GLP-1. Keto will actually enhance the GLP-1 pathways (and production?), which is part of the reason it’s so effective. Though it’s really the insulin control that is the most important aspect of keto I think. Which incidentally is one the benefits of GLP-1 agonists – the pathways that lead to weight control lead to better glucose control and reduced insulin which was their original application, diabetes II control.

      Incidentally, I suspect the insomnia is not a direct effect of the GLP-1 agonist but rather downstream of the other more direct impacts in weight loss and glucose/insulin control and the resulting improvement in metabolic health. e.g. any lifestyle change or treatment that has those effects would also improve insomnia.

    • kinnath

      I put that in just for fun

  5. The Other Kevin

    This is fascinating. There are a lot of people in my life struggling with weight loss over their entire lives. What really interests me is how this applies to my oldest daughter, who is severely overweight. We had talked about getting her on a GLP-1 before she ran away in October. Your pop psyche section is dead on. She operates only on id: “This feels good right now so that’s what I’m going to do.” She’s like a drug addict who doesn’t see themselves as having a problem, because they enjoy feeling high. When we mentioned GLP-1’s she seemed horrified: “Why would I want to not eat as much? I love eating!”

    Perhaps some day she’ll come around, and it won’t be the result of a serious health crisis. Until then, you’ve given me a lot of great information, and I thank you for it.

    • Fourscore

      My daughter is extremely overweight. She and husband #3 eat irregularly, stay up late, get up late. They visited over the 4th, I noticed neither ate salads or fruit for dessert. They didn’t forget the trips to the local ice cream emporium and on the trip to Lake Superior stopped in at Betty’s Pies and got a 7 inch $22 Betty Special.

      Very little cooking when they are home and not a lot of physical activity.

      • The Other Kevin

        That’s basically your typical American. Doesn’t know how to cook, or just doesn’t feel like it. Doesn’t eat vegetables aside from corn and potatoes. Enjoys fast food too often. Exercise is dumb, Netflix is better. This describes about 75% of my in-laws.

        My saving grace was my dad had a heart attack at an early age. He stopped smoking, started walking, and took over cooking which was all heart-healthy stuff. He’s in his 80’s now and slowing down, but he’s still pretty active. I learned a lot of good habits from him.

      • Fourscore

        I grew up on taters, they were cheap and we weren’t high buck people. Now I rarely eat spuds but I’m big on my own fresh corn with butter but that’s only for a few weeks in the fall. Now the kohlrabi has grown big, I like fresh stuff in my salad every day. Then the cukes and tomaters will be ready.

        Oh yeah, my daughter and husband were here for a week, didn’t take a single trip down to my garden, which truthfully has overpowered me but still…

      • R C Dean

        She and husband #3 eat irregularly, stay up late, get up late.

        Textbook DST fans, I see.

  6. The Bearded Hobbit

    This is an interesting series for me as I have started using Ozempec.

    I had previously dropped 40 pounds (240 > 200) by a strict low-carb diet and cutting back on alcohol. Three weeks into this program I had lost 3 more pounds. BTW, I’m doing this for diabetes control, rather than weight loss, although I wouldn’t mind dropping some fat.

    The biggest side effect for me was not listed on the instructions. The night following my first injection I did not sleep. At all. I struggle against insomnia anyway and had finally found a process that worked for me most of the time, but Ozempic blew that out of the water. Forewarned is forearmed, as they say, and I’m getting back on schedule, although the night after injection is still rough.

    The other side effect for me was also not listed.

    Last week I met with some friends to have a couple of beers. Halfway though the first beer I had nausea so badly that I had to leave and return home. I haven’t tried a beer since then, so I don’t know if that was a one-time occurrence.

    Thanks for this series, kinnath, I’m following right along with you. This is week 6 for me.

    • kinnath

      Alcohol is reported to amplify the side effects of Zepbound. So, yeah booze can trigger nausea and bowel problems.

    • Ted S.

      Congrats on joining the “beer sucks” group! 😉

      Of course I still drink wine and enjoy vodka….

    • Threedoor

      My wife gets insomnia going low carb. Fasting and magnesium supplementation helps her with it. She has to cut a fine line as to how low carb she goes.

  7. DEG

    Congratulations on the weight loss

  8. Ted S.

    I assume you’re also saving a good deal of money not going out to eat….

    • kinnath

      It helps to offset the $450 a month the meds cost — insurance rejected me.

  9. juris imprudent

    Just chatted with my oldest brother and it turns out both he and I have been scaling back on the pharma products we’ve been prescribed. One of his benefits is he lost the tremor in his hands (from whichever med had that as a side effect). I’ve dumped tamsulosin and solifenacin succinate, both premised to help deal with bladder/prostrate, as I found minimal benefit from them. Switched to some targeted exercises and a couple of supplements. prostrate specific (started with saw palmetto based and recently switched to one with both saw palmetto and beta-siterstol) and L-arginine. Unexpected benefit of the l-arginine (at least so I presume) is it fixed another case of trigger finger.

    • Threedoor

      I was on a bunch of stuff when I was in the army.

      Weaned myself off of everything and have not been on anything for about eight years.

      Cleaning up my diet in the last two years has helped my chronic pain almost as much as getting out of the army and leaving all that garbage stress behind me.

      • juris imprudent

        I’d like to drop my last blood pressure med (lisinopril) too. I’ll be talking with the doc about that on Thurs.

      • Threedoor

        My father in law is on a ton of crap.

        His blood pressure meds inflame him and make his arthritis worse.

        In the long run they are likely to kill him.

        I had a doc I saw once, prescribe me BP meds “for the rest of your life” based on one BP test he didn’t like. I told him to pound sand and refused to see him again. He’s dead now but the Rx he wrote me that I never filled lives on.

      • slumbrew

        I literally talked to my doc about dropping lisonopril last Tuesday. I clocked in there at 116/7x, which isn’t surprising since I lost 30 lbs.

        He was “lower is better but I understand the desire to drop taking a pill if you don’t really need it”.

        I’ve got a good BP cuff so he suggested taking some regular measurements then starting with a half a pill, measuring, etc.

        We’ll see.

      • DrOtto

        “Cleaning up my diet in the last two years has helped my chronic pain…” it’s amazing what a diet of nutrition does over a diet of garbage processed food. *bites into piece of Popeyes fried chicken*

      • PutridMeat

        116/7x

        In what world does 116/70 need to be lower? “Lower is better” – How about 0/0, is that better? I would be asking “That’s interesting Doc, I should be lower than 116/70. Can you share with me the clinical data that shows better outcomes with lower than 116/70?”

      • Threedoor

        Basically it was cutting out seed oils, nuts and vegetables.

        Joint pain almost all gone.

      • Threedoor

        There is no data Putrid.

        Docs get all their prompts from the AHA which was created to push cotton seed and canola oil into the American diet. They don’t ever show you a natural distribution of BP levels and are always pushing it lower. Those meds don’t sell themselves.

      • Contrarian P

        I can definitely say thats a bad take. Lower is not better, especially as you get older. The big question with any intervention is what is your overall risk and then what is it with the intervention. If it’s five percent and goes down to three percent, it’s probably not worth the expense and side effect profile.

      • slumbrew

        For background I’ve been 120/80 on lisinopril for years until I lost the weight; the ‘lower is better’ was in relation to dropping to 116/7x.

        In general he’s great – a lot of his patients are/were high-risk (HIV+ – long, somewhat amusing story as to why I ended up w/ him as my primary – tl;dr – “young slumbrew had no gaydar”) but I think he may have slowed down keeping on top of things the way he used to. When we were talking diet and exercise I got the impression he’s still in the “fat is the devil” camp.

        So, given that, I am indeed looking to transition off of the lisonpril.

      • PutridMeat

        If it’s five percent and goes down to three percent, it’s probably not worth the expense and side effect profile.

        And that’s the sort of nuance one should expect from their Dr. And, if I may go all corporation-y in my corporation building, what you were more likely to get when Drs. were independent agents, not employees of a network of hospitals. A situation that I lay in large part at the feet of things like ACA and its incentives for consolidation. Now lots of Drs are not judged by their patients so much as be whether they followed The Science(tm) as embedded in the Standard of Care, passed down from on high by the priests. Which strangely enough seems to require lots of medicating. Who care’s, you won’t be paying for it! Except through poorer health and increased costs distributed through the whole system via funneling of tax-payer dollars into medical conglomerates and politicians pockets.

        Man I hate sounding like an old smelly hippie.

      • Threedoor

        I usually run around 120-125/85-90

        Get me at the DOT physical and I’m between 130-135/90-95.

        When some stupid arbitrary rule that threatens my livelihood comes up it puts me in a fight or flight reaponce.

    • Furthest Blue pistoffnick (370HSSV)

      …some targeted exercises…

      side effects may include hairy palms, reduced vision, and Popeye-sized forearms. ;^)

    • JaimeRoberto feckful & gruntled

      I used to take saw palmetto, and it did seem to reduce the number of times I had to pee in the night. However I started getting tightness in my chest at night. Not sure that’s quite the right way to describe it, but it was an unpleasant feeling. Apparently it can lead to hyperkalemia, which causes abnormal heartbeats. I figured that didn’t mix well with my cycling. I might start up again but on a lower dose.

    • The Other Kevin

      I’m on 3 blood pressure meds. I’d love to reduce those, but it took months to get the right combination and my current doctor doesn’t want to mess with anything. I would imagine it’s all stress induced, but quitting my job, getting a divorce, and moving in to a Zen monastery is not something I’d consider.

  10. kinnath

    Each part in the series gets fewer comments. Interesting dynamics.

    Time for my afternoon walk. Back in half an hour.

    • UnCivilServant

      I’ve noticed it when serializing stories too.

      Or a multipart review.

      People are just less talkative on later installments.

      • R C Dean

        I think we just tend to say our piece on the first go-round.

    • Threedoor

      It’s interesting.

      Not anything I would do unless in dire straights.

      I’m glad you are having positive results as I’ve heard some horror stories.

      • kinnath

        unless in dire straights.

        The future is mostly grim for a morbidly obese 69-yr-old who’s been taking blood pressure meds for a decade and a half.

        The calculus of risk versus benefits of using a relatively new med potentially for life is a lot easier for people in my situation than someone in mid life.

      • slumbrew

        Indeed, as previously discussed, I’m 100% on board with your thinking; I’d love for my MIL to get on a GLP-1 agonist.

        There _may_ be long-term side-effects. The 70(?) extra pounds she’s carrying _will_ kill her early.

      • Threedoor

        Your risk reward calculation is a good trade off.

      • kinnath

        thanks

    • trshmnstr

      Yeah, I noticed it back when I wrote more regularly, too. I reduced the effort level of my posts because people seemed to appreciate lower effort posts with one or two points and a link more than multi-hour researched articles split into multiple parts.

      Once I made that change, it was much easier to accept when later installments in a series didn’t get much traction. People read them, some commented, but it was primarily a vehicle for other conversation.

      • kinnath

        This post is the opportunity for people to bring out the knives and go for the jugular.

        Surprisingly, Zepbound has done nothing to alleviate my cynicsm.

        Nor has it helped my golf game. I’m gonna need to find a lawyer.

      • (((Jarflax

        To make you feel less cynical and more skilled at golf by comparison?

      • kinnath

        I need to sue someone to cover the cost of Zepbound. Lilly has very, very deep pockets at the moment.

        Just need to put in a little creative thinking to identify the tort.

      • (((Jarflax

        Suing to cover the cost is not going to interest any Lawyers. You need to claim something bigger. Like Zepbound turned you libertarian and now your life is ruined, no one except reprobates like you, you are an enemy of the State, and you can no longer attend parties.

      • Ted S.

        Lily peed on your carpet?

        Although I didn’t think Not Adahn had deep pockets.

      • kinnath

        Id: What has Lilly done for me?

        Ego: There’s the weight loss

        Id: Ok, weight loss. But what else has Lilly done for me?

        Ego: There’s the improved glucose levels

        Id: ok, better glucose. But what else has Lilly done for me?

        Ego: The lower blood pressure.

        Id: Fine, blood pressure. But what else has Lilly done for me?

        Ego: Well, the insomnia gone.

        Id: Yes Lilly got my weight down, lowered my glucose and blood pressure, and lets me sleep at night. But what else has Lilly done for me recently?

        Ego: Well, your golf game still sucks.

        Id: Eureka!

    • ron73440

      I think there are more questions for the earlier ones, then not as much to say.

  11. slumbrew

    I no doubt pimped it during the previous installments but I will again:

    Nick Norwitz’s substack is great if you’re interested in this stuff:

    https://staycuriousmetabolism.substack.com/

    (h/t to Tundra, wherever he may be)

    Recent, related posts:

    GLP-1s Don’t Cause Selective Loss Muscle Mass (New Data)

    The Evolutions of GLP-1 Drugs for Weight Loss

    I Answered Retatrutide’s Biggest Unanswered Questions

    GLP-1s for Alzheimer’s Disease and Dementia Prevention

    How GLP-1s Rewire Taste

    What To Do If Your GLP-1 Stops Working

  12. ron73440

    Wish these had been around for my mom.

    She was 5′ 5″ and weighed between 280-300 pounds.

    She would start a diet and go walking in the pool at the gym and do that for a couple months, then quit.

    When she wasn’t on her “diet”, she ate A LOT.

    She definitely could have benefited from a brain rewiring.

  13. Not Adahn

    Re: time zones.

    The sun at it’s highest point on the equinox at 0 degrees longitude is 12:00 noon. Every 15 degrees longitude east or west is an hour off.

    You’re welcome.

  14. Not Adahn

    SIG is very short on cash these days. This will be my most expensive match ever.

    On the flip side I picked up a handle of JW Black for $50 and bottles of The Glenlivet 14yr and Founder’s Reserve for less than that.

  15. Fourscore

    Thanks, Kinnath,

    You have a lot of us talking about those problems we wished we never had. Like JI I see no benefit from the tamsulosin, I get my nightly exercise at least twice, 3-4 is not unusual. Now I have high blood pressure but you know, I don’t care.

  16. The Late P Brooks

    Each part in the series gets fewer comments.

    I’m not sure I have much to add. I have been on an apple cider vinegar concoction, which seems to have some very similar effects, especially so far as appetite suppression and satiation. This was prompted by a serious difficulty buttoning a specific pair of pants, Since starting, I have seen exactly no change on the scale, but visible reduction in belly fat and those pants fit much better. I still suffer portion control based on habit and inertia. Like your lunch story, I find myself asking, “Why did I fix all this? I’m stuffed.”

    Also- blood pressure: I have zero interest in meeting a number the Pharma Guild pulled out of its ass to promote lifetime prescription services.

  17. The Late P Brooks

    At this point my biggest crime is being far too sedentary.

    • Threedoor

      A rolling stone gathers no moss.

      Try going for a gneiss walk.

  18. R.J.

    I have been busting tail at work. Apologies for not being around to comment in the day.
    Now in to some furniture assembly.

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